A common genetic variant is associated with adult and childhood obesity by Herbert Alan, Gerry Norman P, McQueen Matthew B, Heid Iris M, Pfeufer Arne, Illig Thomas, Wichmann H-Erich, Meitinger Thomas, Hunter David, Hu Frank B, Colditz Graham, Hinney Anke, Hebebrand Johannes, Koberwitz Kerstin, Zhu Xiaofeng, Cooper Richard, Ardlie Kristin, Lyon Helen, Hirschhorn Joel N, Laird Nan M, Lenburg Marc E, Lange Christoph, Christman Michael F in Science (New York, N.Y.) (2006).

[PMID: 16614226] PubMed


Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.

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