The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes by Sesti Giorgio, Laratta Emanuela, Cardellini Marina, Andreozzi Francesco, Del Guerra Silvia, Irace Concetta, Gnasso Agostino, Grupillo Maria, Lauro Renato, Hribal Marta Letizia, Perticone Francesco, Marchetti Piero in The Journal of clinical endocrinology and metabolism (2006).

[PMID: 16595597] PubMed


Several studies suggest that genetic factors may play a role in the different responses to antidiabetic therapy; however, conclusive evidence is still lacking.

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