Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies by Greenblatt David J, von Moltke Lisa L, Perloff Elke Störmer, Luo Yan, Harmatz Jerold S, Zinny Miguel A in Clinical pharmacology and therapeutics (2006).

[PMID: 16413247] PubMed


Recent anecdotal, unvalidated case reports have suggested potentiation of warfarin-induced anticoagulation by cranberry juice, possibly through inhibition of human cytochrome P450 (CYP) 2C9, the enzyme responsible for the clearance of the active S-enantiomer of warfarin. To address this question, the effect of cranberry juice and other beverages on CYP2C9 activity was evaluated in vitro and in vivo.

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