Elevated peptide YY levels in adolescent girls with anorexia nervosa by Misra Madhusmita, Miller Karen K, Tsai Patrika, Gallagher Katie, Lin Alvin, Lee Noel, Herzog David B, Klibanski Anne in The Journal of clinical endocrinology and metabolism (2006).

[PMID: 16278259] PubMed


Peptide YY (PYY) is an intestinally derived anorexigen that acts via the Y2 receptor, and Y2 receptor deletion in rodents increases bone formation. Anorexia nervosa (AN) is associated with a deliberate reduction in food intake and low bone density, but endocrine modulators of food intake in AN are not known. In addition, known regulators of bone turnover, such as GH, cortisol, and estrogen, explain only a fraction of the variability in bone turnover marker levels.

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