Does the Angiotensin-converting enzyme (ACE) gene insertion/deletion polymorphism modify the response to ACE inhibitor therapy?--A systematic review by Scharplatz Madlaina, Puhan Milo A, Steurer Johann, Perna Annalisa, Bachmann Lucas M in Current controlled trials in cardiovascular medicine (2005).

[PMID: 16242049] PubMed


Pharmacogenetic testing to individualize ACE inhibitor therapy remains controversial. We conducted a systematic review to assess the effect modification of the insertion/deletion (I/D) polymorphism of the ACE gene on any outcome in patients treated with ACE inhibitors for cardiovascular and/or renal disease.

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