Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men by Zhang Cuilin, Lopez-Ridaura Ruy, Rimm Eric B, Rifai Nader, Hunter David J, Hu Frank B in The American journal of clinical nutrition (2005).

[PMID: 15941898] PubMed


Low plasma HDL-cholesterol concentrations are a hallmark of diabetic dyslipidemia. A common polymorphism (-514C-->T) of the hepatic lipase gene (LIPC), which accounts for up to 30% of the variation in hepatic lipase activity, has been associated with low hepatic lipase activity and high HDL-cholesterol concentrations.

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