Alpha-2B adrenoceptor polymorphism and peripheral vasoconstriction by Talke Pekka, Stapelfeldt Claudia, Lobo Errol, Brown Ronald, Scheinin Mika, Snapir Amir in Pharmacogenetics and genomics (2005).

[PMID: 15864138] PubMed


Alpha-2B adrenoceptors (AR) mediate vasoconstriction in the mice. A human alpha-2B AR deletion (D) variant has been associated with loss of short-term agonist-promoted receptor desensitization, which may lead to increased vasoconstriction upon alpha-2 AR activation. This study tested the hypothesis that alpha-2 AR activation will induce enhanced vasoconstriction in carriers of the alpha-2B AR DD genotype, compared to carriers of the II or the DI genotypes.

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