Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia by Bertolino Alessandro, Caforio Grazia, Blasi Giuseppe, De Candia Mariapia, Latorre Valeria, Petruzzella Vittoria, Altamura Mario, Nappi Gaetano, Papa Sergio, Callicott Joseph H, Mattay Venkata S, Bellomo Antonello, Scarabino Tommaso, Weinberger Daniel R, Nardini Marcello in The American journal of psychiatry (2004).

[PMID: 15465976] PubMed


Deficits in working memory and in prefrontal cortical physiology are important outcome measures in schizophrenia, and both have been associated with dopamine dysregulation and with a functional polymorphism (Val(108/158)Met) in the catechol O-methyltransferase (COMT) gene that affects dopamine inactivation in the prefrontal cortex. The purpose of the present study was to evaluate in patients with schizophrenia the effect of COMT genotype on symptom variation, working memory performance, and prefrontal cortical physiology in response to treatment with an atypical antipsychotic drug.

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