Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility by Buono R J, Lohoff F W, Sander T, Sperling M R, O'Connor M J, Dlugos D J, Ryan S G, Golden G T, Zhao H, Scattergood T M, Berrettini W H, Ferraro T N in Epilepsy research (2004).

[PMID: 15120748] PubMed


Our research program uses genetic linkage and association analysis to identify human seizure sensitivity and resistance alleles. Quantitative trait loci mapping in mice led to identification of genetic variation in the potassium ion channel gene Kcnj10, implicating it as a putative seizure susceptibility gene. The purpose of this work was to translate these animal model data to a human genetic association study.

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