Genetic variants in the UDP-glucuronosyltransferase 1A1 gene predict the risk of severe neutropenia of irinotecan by Innocenti Federico, Undevia Samir D, Iyer Lalitha, Chen Pei Xian, Das Soma, Kocherginsky Masha, Karrison Theodore, Janisch Linda, Ramírez Jacqueline, Rudin Charles M, Vokes Everett E, Ratain Mark J in Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2004).

[PMID: 15007088] PubMed


Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the active metabolite SN-38. This study prospectively evaluated the association between the prevalence of severe toxicity and UGT1A1 genetic variation.

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