Association of multidrug resistance in epilepsy with a polymorphism in the drug-transporter gene ABCB1 by Siddiqui Asra, Kerb Reinhold, Weale Michael E, Brinkmann Ulrich, Smith Alice, Goldstein David B, Wood Nicholas W, Sisodiya Sanjay M in The New England journal of medicine (2003).

[PMID: 12686700] PubMed


One third of patients with epilepsy have drug-resistant epilepsy, which is associated with an increased risk of death and debilitating psychosocial consequences. Because this form is resistant to multiple antiepileptic drugs, the mode of resistance must be nonspecific, involving drug-efflux transporters such as ATP-binding cassette sub-family B member 1 (ABCB1, also known as MDR1 and P-glycoprotein 170). We hypothesized that the CC genotype at the ABCB1 C3435T polymorphism, which is associated with increased expression of the protein, influences the response to antiepileptic-drug treatment.

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