Genetic origins of anxiety in women: a role for a functional catechol-O-methyltransferase polymorphism by Enoch Mary-Anne, Xu Ke, Ferro Erica, Harris Claudia R, Goldman David in Psychiatric genetics (2003).

[PMID: 12605099] PubMed


Women are more prone to anxiety than men. The catechol- -methyltransferase functional polymorphism, Val158Met, is likely to be implicated in anxiety vulnerability. We hypothesized that, particularly in women, the low-activity Met158 allele would be associated with higher anxiety scores and a biological trait, low-voltage alpha resting electroencephalogram (EEG), previously associated with alcoholism and anxiety disorders.

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