Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction by Pacher Pál, Liaudet Lucas, Bai Péter, Mabley Jon G, Kaminski Pawel M, Virág László, Deb Amitabha, Szabó Eva, Ungvári Zoltán, Wolin Michael S, Groves John T, Szabó Csaba in Circulation (2003).

[PMID: 12591762] PubMed


Increased oxidative stress and dysregulation of nitric oxide have been implicated in the cardiotoxicity of doxorubicin (DOX), a commonly used antitumor agent. Peroxynitrite is a reactive oxidant produced from nitric oxide and superoxide in various forms of cardiac injury. Using a novel metalloporphyrinic peroxynitrite decomposition catalyst, FP15, and nitric oxide synthase inhibitors or knockout mice, we now delineate the pathogenetic role of peroxynitrite in rodent models of DOX-induced cardiac dysfunction.

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