Chlorproguanil-dapsone versus sulfadoxine-pyrimethamine for sequential episodes of uncomplicated falciparum malaria in Kenya and Malawi: a randomised clinical trial by Sulo J, Chimpeni P, Hatcher J, Kublin J G, Plowe C V, Molyneux M E, Marsh K, Taylor T E, Watkins W M, Winstanley P A in Lancet (2002).

[PMID: 12387962] PubMed


Chlorproguanil-dapsone exerts lower resistance pressure on Plasmodium falciparum than does sulfadoxine-pyrimethamine, but is rapidly eliminated. We aimed to find out whether chlorproguanil-dapsone results in a higher retreatment rate for malaria than sulfadoxine-pyrimethamine.

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