Neurocognitive correlates of the COMT Val(158)Met polymorphism in chronic schizophrenia by Bilder Robert M, Volavka Jan, Czobor Pál, Malhotra Anil K, Kennedy James L, Ni Xingqun, Goldman Robert S, Hoptman Matthew J, Sheitman Brian, Lindenmayer Jean-Pierre, Citrome Leslie, McEvoy Joseph P, Kunz Michal, Chakos Miranda, Cooper Thomas B, Lieberman Jeffrey A in Biological psychiatry (2002).

[PMID: 12372660] PubMed


Neurocognitive deficits are recognized as a cardinal feature of schizophrenia, but the determinants of these deficits remain unknown. Recent reports have suggested that a functional polymorphism, Val(158)Met in exon III of the catechol-O-methyltransferase gene, shares approximately 4% variance with performance on the Wisconsin Card Sorting Test. These findings led to suggestions that the catechol-O-methyltransferase polymorphism may exert its effects by modulating prefrontal dopamine function, but few other neurocognitive measures have been examined, leaving open questions about phenotypic specificity.

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