Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P-glycoprotein by Kurata Yasuo, Ieiri Ichiro, Kimura Miyuki, Morita Toshihiro, Irie Shin, Urae Akinori, Ohdo Shigehiro, Ohtani Hisakazu, Sawada Yasufumi, Higuchi Shun, Otsubo Kenji in Clinical pharmacology and therapeutics (2002).

[PMID: 12189368] PubMed

Abstract

Our objective was to quantitate the contribution of the genetic polymorphism of the human MDR1 gene to the bioavailability and interaction profiles of digoxin, a substrate of P-glycoprotein.

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