Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers by DeVane C L, Markowitz J S, Carson S W, Boulton D W, Gill H S, Nahas Z, Risch S C in Journal of clinical psychopharmacology (2000).

[PMID: 10831022] PubMed


Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 (CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had no significant effect on the pharmacokinetics of either MPH or ritalinic acid, its major metabolite, in either group of CYP2D6 metabolizers. These data suggest a lack of involvement of CYP2D6 in the metabolism of MPH. Drugs that are inhibitors of CYP2D6 when taken concurrently with MPH should not affect its plasma concentration.

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