Use of the selective oral neuraminidase inhibitor oseltamivir to prevent influenza by Hayden F G, Atmar R L, Schilling M, Johnson C, Poretz D, Paar D, Huson L, Ward P, Mills R G in The New England journal of medicine (1999).

[PMID: 10536125] PubMed


Safe and effective antiviral agents are needed to prevent infection with influenza A and B virus. Oseltamivir (GS4104), which can be administered orally, is the prodrug of GS4071, a potent and selective inhibitor of influenzavirus neuraminidases. We studied the use of oseltamivir for long-term prophylaxis against influenza in two placebo-controlled, double-blind trials at different U.S. sites during the winter of 1997-1998.

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