Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine by Sachse C, Brockmöller J, Bauer S, Roots I in British journal of clinical pharmacology (1999).

[PMID: 10233211] PubMed


The cytochrome P450 enzyme CYP1A2 metabolises several drugs and carcinogens. We wanted to determine how much of the variability of CYP1A2 activity is explained by a newly discovered gene polymorphism in intron 1.

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