Pathway Benzodiazepine Pathway, Pharmacokinetics

Diagrammatic representation of the metabolism of different benzodiazepine drugs by candidate genes.
Benzodiazepine Pathway, Pharmacokinetics
Therapeutic Categories:
  • Neurological agents

Entities in the Pathway

Genes (11)

Drugs/Drug Classes (11)

Relationships in the Pathway

Arrow FromArrow ToControllersPMID
alprazolam hydroxyalprazolam CYP3A4, CYP3A5 17635335
bromazepam Glucoronidation 18855614
bromazepam hydroxybromezepam CYP1A2, CYP2D6 18855614
clonazepam acetylation NAT2 19356010, 7273597
diazepam nordazepam CYP2C19, CYP3A4 17635335, 18855614
diazepam temazepam CYP3A4 18855614
flunitrazepam hydroxyflunitrazepam CYP2C19, CYP3A4 17635335
flunitrazepam N-desmethylflunitrazepam CYP2C19, CYP3A4 17635335
flurazepam hydroxyflurazepam
flurazepam N des-alkylflurazepam
hydroxyalprazolam Glucoronidation
hydroxybromezepam Glucoronidation
hydroxyflunitrazepam Glucoronidation
hydroxyflurazepam Glucoronidation
hydroxymidazolam Glucoronidation UGT1A4, UGT2B4, UGT2B7 18855614
hydroxytriazolam Glucoronidation
lorazepam Glucoronidation UGT2B15 18855614
midazolam Glucoronidation UGT1A4 18256203, 18855614
midazolam hydroxymidazolam CYP3A4, CYP3A5 17635335, 18855614
N des-alkylflurazepam Glucoronidation
N-desmethylflunitrazepam Glucoronidation
nordazepam oxazepam CYP3A4 18855614
oxazepam Glucoronidation UGT1A9, UGT2B15, UGT2B7 12386133
temazepam oxazepam CYP2C19, CYP3A4 18855614
triazolam hydroxytriazolam CYP3A4, CYP3A5 17635335, 18855614

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