Gene:
CAMK2B
calcium/calmodulin-dependent protein kinase II beta

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  CAMKB; CaM kinase II beta subunit; CaM-kinase II beta chain; calcium/calmodulin-dependent protein kinase type II beta chain; proline rich calmodulin-dependent protein kinase
Alternate Symbols:  CAM2; CAMK2
PharmGKB Accession Id: PA91

Details

Cytogenetic Location: chr7 : p14.3 - p14.1
GP mRNA Boundary: chr7 : 44256749 - 44365230
GP Gene Boundary: chr7 : 44253749 - 44375230
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. EGFR Inhibitor Pathway, Pharmacodynamics
    Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.

External Pathways

Links to non-PharmGKB pathways.

  1. actions of nitric oxide in the heart - (BioCarta via Pathway Interaction Database)
  2. angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling - (BioCarta via Pathway Interaction Database)
  3. bcr signaling pathway - (BioCarta via Pathway Interaction Database)
  4. bioactive peptide induced signaling pathway - (BioCarta via Pathway Interaction Database)
  5. ca-calmodulin-dependent protein kinase activation - (BioCarta via Pathway Interaction Database)
  6. calcium signaling by hbx of hepatitis b virus - (BioCarta via Pathway Interaction Database)
  7. control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) - (BioCarta via Pathway Interaction Database)
  8. corticosteroids and cardioprotection - (BioCarta via Pathway Interaction Database)
  9. effects of calcineurin in keratinocyte differentiation - (BioCarta via Pathway Interaction Database)
  10. endocytotic role of ndk phosphins and dynamin - (BioCarta via Pathway Interaction Database)
  11. fmlp induced chemokine gene expression in hmc-1 cells - (BioCarta via Pathway Interaction Database)
  12. IFN-gamma pathway - (Pathway Interaction Database NCI-Nature Curated)
  13. ion channels and their functional role in vascular endothelium - (BioCarta via Pathway Interaction Database)
  14. links between pyk2 and map kinases - (BioCarta via Pathway Interaction Database)
  15. nfat and hypertrophy of the heart - (BioCarta via Pathway Interaction Database)
  16. nitric oxide signaling pathway - (BioCarta via Pathway Interaction Database)
  17. p38 MAPK signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  18. pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase - (BioCarta via Pathway Interaction Database)
  19. regulation of ck1/cdk5 by type 1 glutamate receptors - (BioCarta via Pathway Interaction Database)
  20. regulation of pgc-1a - (BioCarta via Pathway Interaction Database)
  21. role of mef2d in t-cell apoptosis - (BioCarta via Pathway Interaction Database)
  22. signal dependent regulation of myogenesis by corepressor mitr - (BioCarta via Pathway Interaction Database)
  23. signaling pathway from g-protein families - (BioCarta via Pathway Interaction Database)
  24. stathmin and breast cancer resistance to antimicrotubule agents - (BioCarta via Pathway Interaction Database)
  25. t cell receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  26. transcription factor creb and its extracellular signals - (BioCarta via Pathway Interaction Database)
  27. vegf hypoxia and angiogenesis - (BioCarta via Pathway Interaction Database)

Curated Information ?

No related diseases are available

LinkOuts

MutDB:
CAMK2B
HuGE:
CAMK2B
Comparative Toxicogenomics Database:
816
ModBase:
Q9UGH7
HumanCyc Gene:
HS00722
HGNC:
1461

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