PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|Alternate Names:||DFNA14; DFNA38; DFNA6|
|Alternate Symbols:||DIDMOAD; WFS|
|PharmGKB Accession Id:||PA37365|
|Cytogenetic Location:||chr4 : p16.1 - p16.1|
|GP mRNA Boundary†:||chr4 : 6271577 - 6304992|
|GP Gene Boundary†:||chr4 : 6261577 - 6307992|
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.View on UCSC Browser
Publications related to WFS1: 5
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
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||Pharmacogenetic aspects of the treatment of Type 2 diabetes with the incretin effect enhancers. Pharmacogenomics. 2016. Tkáč Ivan, et al.|
||The search for putative unifying genetic factors for components of the metabolic syndrome. Diabetologia. 2008. Sjögren M, et al.|
||Clinical risk factors, DNA variants, and the development of type 2 diabetes. The New England journal of medicine. 2008. Lyssenko Valeriya, et al.|
||A homozygous mutation in a novel zinc-finger protein, ERIS, is responsible for Wolfram syndrome 2. American journal of human genetics. 2007. Amr Sami, et al.|
||Common variants in WFS1 confer risk of type 2 diabetes. Nature genetics. 2007. Sandhu Manjinder S, et al.|