Gene:
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for UCP2

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs586773 NC_000011.10:g.73985565A>T, NC_000011.9:g.73696610A>T, NG_011478.1:g.2280T>A, rs59870849
A > T
SNP
No VIP available No Clinical Annotations available VA
rs591758 NC_000011.10:g.73987015G>C, NC_000011.9:g.73698060G>C, NG_011478.1:g.830C>G, rs58859716
G > A
G > C
SNP
No VIP available No Clinical Annotations available VA
rs649446 NC_000011.10:g.73984800C>T, NC_000011.9:g.73695845C>T, NG_011478.1:g.3045G>A, NM_003355.2:c.-2336G>A, rs60982407
C > T
SNP
No VIP available No Clinical Annotations available VA
rs655717 NC_000011.10:g.73973170A>G, NC_000011.9:g.73684215A>G, NG_011478.1:g.14675T>C, rs17244706, rs386603512, rs58444401
A > G
SNP
No VIP available No Clinical Annotations available VA
rs659366 NC_000011.10:g.73983709C>T, NC_000011.9:g.73694754C>T, NG_011478.1:g.4136G>A, NM_003355.2:c.-1245G>A, rs17174147, rs3829934, rs52801495, rs59575906
C > T
SNP
No VIP available No Clinical Annotations available VA
rs660339 NC_000011.10:g.73978059G>A, NC_000011.9:g.73689104G>A, NG_011478.1:g.9786C>T, NM_003355.2:c.164C>T, NP_003346.2:p.Ala55Val, rs1050841, rs117907410, rs17848359, rs2228495, rs59652865
G > A
SNP
A55V
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  BMIQ4
Alternate Symbols:  SLC25A8
PharmGKB Accession Id: PA37165

Details

Cytogenetic Location: chr11 : q13.4 - q13.4
GP mRNA Boundary: chr11 : 73685716 - 73693889
GP Gene Boundary: chr11 : 73682716 - 73703889
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. FOXA2 and FOXA3 transcription factor networks - (Pathway Interaction Database NCI-Nature Curated)

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
DNAJB13

Curated Information ?

Curated Information ?

Publications related to UCP2: 5

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenomics of glinides. Pharmacogenomics. 2015. Chen Miao, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Association of an UCP4 (SLC25A27) haplotype with ultra-resistant schizophrenia. Pharmacogenomics. 2011. Mouaffak Fayçal, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Interaction between the UCP2 -866 G>A polymorphism, diabetes, and beta-blocker use among patients with acute coronary syndromes. Pharmacogenetics and genomics. 2010. Beitelshees Amber L, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. Clinica chimica acta; international journal of clinical chemistry. 2009. Ruaño Gualberto, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nature genetics. 2001. Esterbauer H, et al. PubMed

LinkOuts

NCBI Gene:
7351
OMIM:
601665
601693
606641
607447
UCSC Genome Browser:
NM_003355
RefSeq RNA:
NM_003355
RefSeq Protein:
NP_003346
RefSeq DNA:
NG_011478
NT_167190
UniProtKB:
UCP2_HUMAN (P55851)
Ensembl:
ENSG00000175567
GenAtlas:
UCP2
GeneCard:
UCP2
MutDB:
UCP2
ALFRED:
LO063981B
HuGE:
UCP2
Comparative Toxicogenomics Database:
7351
ModBase:
P55851
HumanCyc Gene:
HS10953
HGNC:
12518

Common Searches