PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.
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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|Alternate Symbols: ||TRP6|
|PharmGKB Accession Id:||PA37011|
|Cytogenetic Location:||chr11 : q22.1 - q22.1|
|GP mRNA Boundary†:||chr11 : 101322295 - 101454687|
|GP Gene Boundary†:||chr11 : 101319295 - 101464687|
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.View on UCSC Browser
Publications related to TRPC6: 3
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||Effect of VX-770 (Ivacaftor) and OAG on Ca(2+) influx and CFTR activity in G551D and F508del-CFTR expressing cells. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2013. Vachel Laura, et al.|
||Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013. Eltit José M, et al.|
||A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science (New York, N.Y.). 2005. Winn Michelle P, et al.|