Gene:
WRN
Werner syndrome, RecQ helicase-like

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  RECQ3; RECQL2
PharmGKB Accession Id: PA367

Details

Cytogenetic Location: chr8 : p12 - p12
GP mRNA Boundary: chr8 : 30890778 - 31031277
GP Gene Boundary: chr8 : 30880778 - 31034277
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Regulation of Telomerase - (Pathway Interaction Database NCI-Nature Curated)

LinkOuts

Entrez Gene:
7486
OMIM:
277700
604611
UCSC Genome Browser:
NM_000553
RefSeq RNA:
NM_000553
RefSeq Protein:
NP_000544
RefSeq DNA:
AC_000051
AC_000140
NC_000008
NG_008870
NT_167187
NW_001839128
NW_923907
UniProtKB:
WRN_HUMAN (Q14191)
Q59F09_HUMAN (Q59F09)
Ensembl:
ENSG00000165392
GenAtlas:
WRN
GeneCard:
WRN
MutDB:
WRN
ALFRED:
LO002411I
HuGE:
WRN
Comparative Toxicogenomics Database:
7486
ModBase:
Q14191
HumanCyc Gene:
HS09225
HGNC:
12791

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