Gene:
WRN
Werner syndrome, RecQ helicase-like

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  RECQ3; RECQL2
PharmGKB Accession Id: PA367

Details

Cytogenetic Location: chr8 : p12 - p12
GP mRNA Boundary: chr8 : 30890778 - 31031277
GP Gene Boundary: chr8 : 30880778 - 31034277
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
antineoplastic agents

Curated Information ?

Publications related to WRN: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Determining the frequency of pathogenic germline variants from exome sequencing in patients with castrate-resistant prostate cancer. BMJ open. 2016. Hart Steven N, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy. Breast cancer research and treatment. 2015. Ellingson Marissa S, et al. PubMed

LinkOuts

NCBI Gene:
7486
OMIM:
277700
604611
UCSC Genome Browser:
NM_000553
RefSeq RNA:
NM_000553
RefSeq Protein:
NP_000544
RefSeq DNA:
NG_008870
NT_167187
UniProtKB:
WRN_HUMAN (Q14191)
Q59F09_HUMAN (Q59F09)
Ensembl:
ENSG00000165392
GenAtlas:
WRN
GeneCard:
WRN
MutDB:
WRN
ALFRED:
LO002411I
HuGE:
WRN
Comparative Toxicogenomics Database:
7486
ModBase:
Q14191
HumanCyc Gene:
HS09225
HGNC:
12791

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