transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

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The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Alternate Names:  enhancer of split groucho 1
Alternate Symbols:  ESG; ESG1; GRG1
PharmGKB Accession Id: PA36539


Cytogenetic Location: chr9 : q21.32 - q21.32
GP mRNA Boundary: chr9 : 84198598 - 84303596
GP Gene Boundary: chr9 : 84195598 - 84313596
Strand: minus


UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Canonical Wnt signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  2. Presenilin action in Notch and Wnt signaling - (Pathway Interaction Database NCI-Nature Curated)
  3. wnt signaling pathway - (BioCarta via Pathway Interaction Database)

Publications related to TLE1: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Significant linkage evidence for a predisposition gene for pelvic floor disorders on chromosome 9q21. American journal of human genetics. 2009. Allen-Brady Kristina, et al. PubMed


NCBI Gene:
UCSC Genome Browser:
RefSeq RNA:
RefSeq Protein:
Comparative Toxicogenomics Database:

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