Gene:
NKX2-1
NK2 homeobox 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  BCH; NKX2A; TITF1
Alternate Symbols:  TTF-1; TTF1
PharmGKB Accession Id: PA36531

Details

Cytogenetic Location: chr14 : q13.3 - q13.3
GP mRNA Boundary: chr14 : 36985602 - 36990894
GP Gene Boundary: chr14 : 36982602 - 37000894
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. FOXA2 and FOXA3 transcription factor networks - (Pathway Interaction Database NCI-Nature Curated)

LinkOuts

NCBI Gene:
7080
OMIM:
118700
600635
610978
UCSC Genome Browser:
NM_003317
RefSeq RNA:
NM_001079668
NM_003317
XM_002344771
RefSeq Protein:
NP_001073136
NP_003308
XP_002344812
RefSeq DNA:
NG_013365
NT_026437
UniProtKB:
NKX21_HUMAN (P43699)
Ensembl:
ENSG00000136352
GenAtlas:
TITF1
GeneCard:
NKX2-1
TITF1
MutDB:
TITF1
ALFRED:
LO177397I
HuGE:
TITF1
Comparative Toxicogenomics Database:
7080
HumanCyc Gene:
HS06150
HGNC:
11825

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