Gene:
THPO
thrombopoietin

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  MGDF; MPL ligand; c-mpl ligand; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; megakaryocyte stimulating factor; myeloproliferative leukemia virus oncogene ligand; prepro-thrombopoietin; thrombopoietin nirs variant 1
Alternate Symbols:  MPLLG; TPO
PharmGKB Accession Id: PA36506

Details

Cytogenetic Location: chr3 : q27.1 - q27.1
GP mRNA Boundary: chr3 : 184089773 - 184097368
GP Gene Boundary: chr3 : 184086773 - 184107368
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

LinkOuts

NCBI Gene:
7066
OMIM:
187950
600044
UCSC Genome Browser:
NM_000460
RefSeq RNA:
NM_000460
NM_001177597
NM_001177598
RefSeq Protein:
NP_000451
NP_001171068
NP_001171069
RefSeq DNA:
NG_012136
NT_005612
UniProtKB:
TPO_HUMAN (P40225)
Q5FBX8_HUMAN (Q5FBX8)
Ensembl:
ENSG00000090534
GenAtlas:
THPO
GeneCard:
THPO
MutDB:
THPO
ALFRED:
LO035838B
HuGE:
THPO
Comparative Toxicogenomics Database:
7066
ModBase:
P40225
HumanCyc Gene:
HS01694
HGNC:
11795

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