Gene:
PLK4
polo-like kinase 4

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  STK18
Alternate Symbols:  Sak
PharmGKB Accession Id: PA36205

Details

Cytogenetic Location: chr4 : q28.2 - q28.2
GP mRNA Boundary: chr4 : 128802016 - 128820379
GP Gene Boundary: chr4 : 128792016 - 128823379
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

LinkOuts

NCBI Gene:
10733
OMIM:
605031
UCSC Genome Browser:
NM_014264
RefSeq RNA:
NM_001190799
NM_001190801
NM_014264
RefSeq Protein:
NP_001177728
NP_001177730
NP_055079
RefSeq DNA:
NT_016354
UniProtKB:
PLK4_HUMAN (O00444)
Ensembl:
ENSG00000142731
GenAtlas:
PLK4
GeneCard:
PLK4
MutDB:
PLK4
ALFRED:
LO145474Z
HuGE:
PLK4
Comparative Toxicogenomics Database:
10733
ModBase:
O00444
HumanCyc Gene:
HS06956
HGNC:
11397

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