Gene:
STIP1
stress-induced phosphoprotein 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for STIP1

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs11607165
T > G
SNP
No VIP available No Clinical Annotations available VA
rs2070232
G > A
SNP
A484A
No VIP available No Clinical Annotations available VA
rs2236647
C > T
SNP
No VIP available No Clinical Annotations available VA
rs2236648
C > T
SNP
No VIP available No Clinical Annotations available VA
rs2282490
T > C
SNP
No VIP available No Clinical Annotations available VA
rs2701528
A > G
SNP
No VIP available No Clinical Annotations available VA
rs3751122
G > A
G > T
SNP
No VIP available No Clinical Annotations available VA
rs3751123
G > A
SNP
No VIP available No Clinical Annotations available VA
rs4980524
A > C
SNP
No VIP available No Clinical Annotations available VA
rs6591838
A > G
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  Hsp70/Hsp90-organizing protein; stress-induced-phosphoprotein 1
Alternate Symbols:  HOP; STI1
PharmGKB Accession Id: PA36196

Details

Cytogenetic Location: chr11 : q13.1 - q13.1
GP mRNA Boundary: chr11 : 63952206 - 63972020
GP Gene Boundary: chr11 : 63942206 - 63975020
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Asthma

Publications related to STIP1: 3

No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
No evidence of large genetic effects on steroid response in asthma patients. The Journal of allergy and clinical immunology. 2016. Mosteller Michael, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Integrative systems biology approaches in asthma pharmacogenomics. Pharmacogenomics. 2012. Dahlin Amber, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The pharmacogenetics and pharmacogenomics of asthma therapy. The pharmacogenomics journal. 2011. Tse S M, et al. PubMed

LinkOuts

NCBI Gene:
10963
OMIM:
605063
UCSC Genome Browser:
NM_006819
RefSeq RNA:
NM_006819
RefSeq Protein:
NP_006810
RefSeq DNA:
NT_167190
UniProtKB:
STIP1_HUMAN (P31948)
Ensembl:
ENSG00000168439
GenAtlas:
STIP1
GeneCard:
STIP1
MutDB:
STIP1
ALFRED:
LO064005P
HuGE:
STIP1
Comparative Toxicogenomics Database:
10963
ModBase:
P31948
HumanCyc Gene:
HS09759
HGNC:
11387

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