Gene:
TRPC1
transient receptor potential cation channel, subfamily C, member 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  HTRP-1
PharmGKB Accession Id: PA357

Details

Cytogenetic Location: chr3 : q23 - q23
GP mRNA Boundary: chr3 : 142443266 - 142526730
GP Gene Boundary: chr3 : 142433266 - 142529730
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
dantrolene
No related diseases are available

Publications related to TRPC1: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Nonspecific sarcolemmal cation channels are critical for the pathogenesis of malignant hyperthermia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013. Eltit José M, et al. PubMed

LinkOuts

NCBI Gene:
7220
OMIM:
602343
UCSC Genome Browser:
NM_003304
RefSeq RNA:
NM_003304
RefSeq Protein:
NP_003295
RefSeq DNA:
NT_005612
UniProtKB:
TRPC1_HUMAN (P48995)
Ensembl:
ENSG00000144935
GenAtlas:
TRPC1
GeneCard:
TRPC1
MutDB:
TRPC1
ALFRED:
LO004205L
HuGE:
TRPC1
ModBase:
P48995
HumanCyc Gene:
HS07219
IUPHAR Receptor:
TRPC1 (486)
HGNC:
12333

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