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PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|Alternate Symbols: ||Nav1.8; PN3; SNS; hPN3|
|PharmGKB Accession Id:||PA35000|
|Cytogenetic Location:||chr3 : p22.2 - p22.2|
|GP mRNA Boundary†:||chr3 : 38738837 - 38835501|
|GP Gene Boundary†:||chr3 : 38735837 - 38845501|
Publications related to SCN10A: 4
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- DG Dosing Guideline information is available
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||Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death. Nature genetics. 2013. Bezzina Connie R, et al.|
||Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2013. Delaney Jessica T, et al.|
||Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation. 2013. Ritchie Marylyn D, et al.|
||Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circulation research. 2012. Yang Tao, et al.|