PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.
PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
|Alternate Names:||BRCA1/BRCA2-containing complex, subunit 5; RAD51 homolog (S. cerevisiae); RAD51A; RECA|
|Alternate Symbols: ||BRCC5; HsRad51; HsT16930|
|PharmGKB Accession Id:||PA34176|
|Cytogenetic Location:||chr15 : q15.1 - q15.1|
|GP mRNA Boundary†:||chr15 : 40987327 - 41024356|
|GP Gene Boundary†:||chr15 : 40977327 - 41027356|
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.View on UCSC Browser
PharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.
Links to non-PharmGKB pathways.
- Assembly of the RAD51-ssDNA nucleoprotein complex - (Reactome via Pathway Interaction Database)
- atm signaling pathway - (BioCarta via Pathway Interaction Database)
- BARD1 signaling events - (Pathway Interaction Database NCI-Nature Curated)
- Presynaptic phase of homologous DNA pairing and strand exchange - (Reactome via Pathway Interaction Database)
- role of brca1 brca2 and atr in cancer susceptibility - (BioCarta via Pathway Interaction Database)
Publications related to RAD51: 4
The following icons indicate that data of a certain type is available:
- DG Dosing Guideline information is available
- DL Drug Label information is available
- CA High-level Clinical Annotation is available
- VA Variant Annotation is available
- VIP VIP information is available
- PW Pathway is available
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||DNA repair and cytotoxic drugs: the potential role of RAD51 in clinical outcome of non-small-cell lung cancer patients. Pharmacogenomics. 2013. Nogueira Augusto, et al.|
||A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. The pharmacogenomics journal. 2010. Ho-Pun-Cheung A, et al.|
||Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy. The pharmacogenomics journal. 2010. Cecchin E, et al.|
||RAD51 135G-->C modifies breast cancer risk among BRCA2 mutation carriers: results from a combined analysis of 19 studies. American journal of human genetics. 2007. Antoniou Antonis C, et al.|