Gene:
PTPN2
protein tyrosine phosphatase, non-receptor type 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  PTPT
Alternate Symbols:  TC-PTP; TCELLPTP; TCPTP
PharmGKB Accession Id: PA33993

Details

Cytogenetic Location: chr18 : p11.21 - p11.21
GP mRNA Boundary: chr18 : 12785477 - 12884337
GP Gene Boundary: chr18 : 12782477 - 12894337
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. IFN-gamma pathway - (Pathway Interaction Database NCI-Nature Curated)
  2. PDGFR-beta signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
No related genes are available

Curated Information ?

Publications related to PTPN2: 4

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nature genetics. 2012. Okada Yukinori, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science (New York, N.Y.). 2009. Nejentsev Sergey, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Shared and distinct genetic variants in type 1 diabetes and celiac disease. The New England journal of medicine. 2008. Smyth Deborah J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer cell. 2002. Yeoh Eng-Juh, et al. PubMed

LinkOuts

NCBI Gene:
5771
OMIM:
176887
UCSC Genome Browser:
NM_002828
RefSeq RNA:
NM_001207013
NM_002828
NM_080422
NM_080423
RefSeq Protein:
NP_001193942
NP_002819
NP_536347
NP_536348
RefSeq DNA:
NT_010859
HuGE:
PTPN2
Comparative Toxicogenomics Database:
5771
ModBase:
P17706
HumanCyc Gene:
HS10919
HGNC:
9650

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