Gene:
STAT5A
signal transducer and activator of transcription 5A

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  STAT5
Alternate Symbols:  MGF
PharmGKB Accession Id: PA338

Details

Cytogenetic Location: chr17 : q11.2 - q21.2
GP mRNA Boundary: chr17 : 40439565 - 40463961
GP Gene Boundary: chr17 : 40429565 - 40466961
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. EGFR Inhibitor Pathway, Pharmacodynamics
    Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.

Curated Information ?

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
glucocorticoids
No related diseases are available

Publications related to STAT5A: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. The Journal of biological chemistry. 2003. Litterst Claudia M, et al. PubMed

LinkOuts

NCBI Gene:
6776
OMIM:
601511
UCSC Genome Browser:
NM_003152
RefSeq RNA:
NM_003152
RefSeq Protein:
NP_003143
RefSeq DNA:
NT_010783
UniProtKB:
A8K6I5_HUMAN (A8K6I5)
STA5A_HUMAN (P42229)
Ensembl:
ENSG00000126561
GenAtlas:
STAT5A
GeneCard:
STAT5A
MutDB:
STAT5A
HuGE:
STAT5A
Comparative Toxicogenomics Database:
6776
ModBase:
P42229
HumanCyc Gene:
HS05032
HGNC:
11366

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