Gene:
PROC
protein C (inactivator of coagulation factors Va and VIIIa)
PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.
Annotated Labels
- Annotation of FDA Label for warfarin and CYP2C9,PROC,PROS1,VKORC1
- Annotation of HCSC Label for drospirenone,ethinyl estradiol and F5,PROC,PROS1,SERPINC1
- Annotation of HCSC Label for ethinyl estradiol,norelgestromin and F2,F5,MTHFR,PROC,PROS1,SERPINC1
1. Annotation of FDA Label for warfarin and CYP2C9,PROC,PROS1,VKORC1
Summary
Warfarin (Coumadin) is an anticoagulant used as a prophylaxis and to treat venous thrombosis, pulmonary embolism, thromboembolic complications from atrial fibrillationa and cardiac valve replacement, and to reduce the recurrence of myocardial infarction. Pharmacogenomics-related dosing information for CYP2C9 and VKORC1 variants is provided within the label. The drug label notes that deficiency in protein C (PROC) or protein S (PROS1) have been associated with tissue necrosis following warfarin administration.
There's more of this label. Read more.
2. Annotation of HCSC Label for drospirenone,ethinyl estradiol and F5,PROC,PROS1,SERPINC1
Summary
The product monograph for drospirenone and ethinyl estradiol (YAZ) states that the drug is contraindicated in women with Factor V Leiden mutation, antithrombin-III-deficiency, protein C deficiency and protein S deficiency (among other contraindications), due to the risk for arterial or venous thrombosis.
There's more of this label. Read more.
3. Annotation of HCSC Label for ethinyl estradiol,norelgestromin and F2,F5,MTHFR,PROC,PROS1,SERPINC1
Summary
The product monograph for norelgestromin and ethinyl estradiol (EVRA) states that the drug is contraindicated in women with Factor V Leiden mutation, antithrombin-III-deficiency, protein C deficiency, protein S deficiency, hyperhomocysteinaemia due to mutations in the MTHFR gene and prothrombin mutation G20210A (among other contraindications), due to the risk for arterial or venous thrombosis.
There's more of this label. Read more.
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.
Links in the "Drugs" column lead to PharmGKB Drug Pages.
List of all variant annotations for PROC
|
Variant?
(147) |
Alternate Names ? | Chemicals ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|
| rs1799808 | NC_000002.11:g.128175862C>T, NC_000002.12:g.127418286C>T, NG_016323.1:g.4867C>T, NM_000312.3:c.-228C>T, XM_005263715.1:c.-161C>T, XM_005263715.3:c.-161C>T, XM_005263716.1:c.-161C>T, XM_005263716.3:c.-161C>T, XM_005263717.1:c.-161C>T, XM_005263717.3:c.-161C>T, rs59400154 |
C > T
|
SNP | |||
| rs1799809 | NC_000002.11:g.128175875G>A, NC_000002.12:g.127418299G>A, NG_016323.1:g.4880G>A, NM_000312.3:c.-215G>A, XM_005263715.1:c.-148G>A, XM_005263715.3:c.-148G>A, XM_005263716.1:c.-148G>A, XM_005263716.3:c.-148G>A, XM_005263717.1:c.-148G>A, XM_005263717.3:c.-148G>A, rs59122016 |
G > A
|
SNP | |||
| rs2069919 | NC_000002.11:g.128179553G>A, NC_000002.12:g.127421977G>A, NG_016323.1:g.8558G>A, NM_000312.3:c.237+528G>A, XM_005263715.1:c.420+528G>A, XM_005263715.3:c.420+528G>A, XM_005263716.1:c.300+528G>A, XM_005263716.3:c.300+528G>A, XM_005263717.1:c.300+528G>A, XM_005263717.3:c.300+528G>A, rs57786626 |
G > A
|
SNP |
Overview
| Alternate Names: | prepro-protein C |
|---|---|
| Alternate Symbols: | None |
| PharmGKB Accession Id: | PA33799 |
Details
| Cytogenetic Location: | chr2 : q13 - q14.3 |
|---|---|
| GP mRNA Boundary†: | chr2 : 128175996 - 128186822 |
| GP Gene Boundary†: | chr2 : 128165996 - 128189822 |
| Strand: | plus |
Visualization
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.
View on UCSC BrowserPharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
-
Warfarin Pathway, Pharmacodynamics
Simplified diagram of the target of warfarin action and downstream genes and effects.
Curated Information ?
| Evidence | Drug |
|---|---|
| drospirenone | |
| ethinyl estradiol | |
| norelgestromin | |
| phenprocoumon | |
| warfarin |
Publications related to PROC: 6
LinkOuts
- UniProtKB:
- PROC_HUMAN (P04070)
- Ensembl:
- ENSG00000115718
- GenAtlas:
- PROC
- GeneCard:
- PROC
- MutDB:
- PROC
- ALFRED:
- LO133899H