WNK lysine deficient protein kinase 1

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for WNK1

Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
No VIP available No Clinical Annotations available VA
rs1159744 NC_000012.11:g.934845C>G, NC_000012.12:g.825679C>G, NG_007984.2:g.77621C>G, NM_001184985.1:c.933-1363C>G, NM_014823.2:c.933-1363C>G, NM_018979.3:c.933-1363C>G, NM_213655.4:c.933-1363C>G, XM_005253733.1:c.933-1363C>G, XM_005253734.1:c.933-1363C>G, XM_005253735.1:c.933-1363C>G, XM_005253736.1:c.933-1363C>G, XM_005253737.1:c.933-1363C>G, XM_005253738.1:c.933-1363C>G, XM_005253739.1:c.933-1363C>G, XM_005253740.1:c.933-1363C>G, XM_005253741.1:c.933-1363C>G, XM_005253742.1:c.933-1363C>G, XM_006719003.1:c.933-1363C>G, XM_011520997.1:c.933-1363C>G, XM_011520998.1:c.933-1363C>G, XM_011520999.1:c.933-1363C>G, XM_011521000.1:c.933-1363C>G, XM_011521001.1:c.933-1363C>G, XM_011521002.1:c.933-1363C>G, XM_011521003.1:c.933-1363C>G, XM_011521004.1:c.933-1363C>G, XM_011521006.1:c.933-1363C>G, XM_011521007.1:c.933-1363C>G, XM_011521008.1:c.933-1363C>G, XM_011521009.1:c.933-1363C>G, rs12823453, rs60332740
C > G
No VIP available No Clinical Annotations available VA
rs2107614 NC_000012.11:g.903079T>C, NC_000012.12:g.793913T>C, NG_007984.2:g.45855T>C, NM_001184985.1:c.760-19729T>C, NM_014823.2:c.760-19729T>C, NM_018979.3:c.760-19729T>C, NM_213655.4:c.760-19729T>C, XM_005253733.1:c.760-19729T>C, XM_005253734.1:c.760-19729T>C, XM_005253735.1:c.760-19729T>C, XM_005253736.1:c.760-19729T>C, XM_005253737.1:c.760-19729T>C, XM_005253738.1:c.760-19729T>C, XM_005253739.1:c.760-19729T>C, XM_005253740.1:c.760-19729T>C, XM_005253741.1:c.760-19729T>C, XM_005253742.1:c.760-19729T>C, XM_006719003.1:c.760-19729T>C, XM_011520997.1:c.760-19729T>C, XM_011520998.1:c.760-19729T>C, XM_011520999.1:c.760-19729T>C, XM_011521000.1:c.760-19729T>C, XM_011521001.1:c.760-19729T>C, XM_011521002.1:c.760-19729T>C, XM_011521003.1:c.760-19729T>C, XM_011521004.1:c.760-19729T>C, XM_011521006.1:c.760-19729T>C, XM_011521007.1:c.760-19729T>C, XM_011521008.1:c.760-19729T>C, XM_011521009.1:c.760-19729T>C, rs60182845
T > C
No VIP available No Clinical Annotations available VA
rs2277869 NC_000012.11:g.1016910T>C, NC_000012.12:g.907744T>C, NG_007984.2:g.159686T>C, NM_001184985.1:c.7424-103T>C, NM_014823.2:c.5900-103T>C, NM_018979.3:c.6644-103T>C, NM_213655.4:c.7400-103T>C, XM_005253733.1:c.7997-103T>C, XM_005253734.1:c.6758-103T>C, XM_005253735.1:c.6755-103T>C, XM_005253736.1:c.6674-103T>C, XM_005253737.1:c.6671-103T>C, XM_005253739.1:c.6017-103T>C, XM_005253740.1:c.5936-103T>C, XM_005253741.1:c.5933-103T>C, XM_005253742.1:c.5822-103T>C, XM_005253743.1:c.5537-103T>C, XM_006719003.1:c.6641-103T>C, XM_011520997.1:c.7883-103T>C, XM_011520998.1:c.7880-103T>C, XM_011520999.1:c.7880-103T>C, XM_011521000.1:c.7688-103T>C, XM_011521001.1:c.7604-103T>C, XM_011521002.1:c.7421-103T>C, XM_011521003.1:c.7145-103T>C, XM_011521004.1:c.7142-103T>C, XM_011521005.1:c.6662-103T>C, XM_011521006.1:c.6560-103T>C, XM_011521007.1:c.6557-103T>C, XM_011521008.1:c.5822-103T>C, XM_011521009.1:c.5819-103T>C, rs57759990
T > C
No VIP available No Clinical Annotations available VA
rs2286007 NC_000012.11:g.971291C>T, NC_000012.12:g.862125C>T, NG_007984.2:g.114067C>T, NM_001184985.1:c.1994C>T, NM_014823.2:c.1994C>T, NM_018979.3:c.1994C>T, NM_213655.4:c.1994C>T, NP_001171914.1:p.Thr665Ile, NP_055638.2:p.Thr665Ile, NP_061852.3:p.Thr665Ile, NP_998820.3:p.Thr665Ile, XM_005253733.1:c.1994C>T, XM_005253734.1:c.1994C>T, XM_005253735.1:c.1994C>T, XM_005253736.1:c.1994C>T, XM_005253737.1:c.1994C>T, XM_005253738.1:c.1994C>T, XM_005253739.1:c.1994C>T, XM_005253740.1:c.1994C>T, XM_005253741.1:c.1994C>T, XM_005253742.1:c.1994C>T, XM_005253743.1:c.773C>T, XM_006719003.1:c.1994C>T, XM_011520997.1:c.1994C>T, XM_011520998.1:c.1994C>T, XM_011520999.1:c.1994C>T, XM_011521000.1:c.1994C>T, XM_011521001.1:c.1994C>T, XM_011521002.1:c.1994C>T, XM_011521003.1:c.1994C>T, XM_011521004.1:c.1994C>T, XM_011521005.1:c.773C>T, XM_011521006.1:c.1994C>T, XM_011521007.1:c.1994C>T, XM_011521008.1:c.1994C>T, XM_011521009.1:c.1994C>T, XP_005253790.1:p.Thr665Ile, XP_005253791.1:p.Thr665Ile, XP_005253792.1:p.Thr665Ile, XP_005253793.1:p.Thr665Ile, XP_005253794.1:p.Thr665Ile, XP_005253795.1:p.Thr665Ile, XP_005253796.1:p.Thr665Ile, XP_005253797.1:p.Thr665Ile, XP_005253798.1:p.Thr665Ile, XP_005253799.1:p.Thr665Ile, XP_005253800.1:p.Thr258Ile, XP_006719066.1:p.Thr665Ile, XP_011519299.1:p.Thr665Ile, XP_011519300.1:p.Thr665Ile, XP_011519301.1:p.Thr665Ile, XP_011519302.1:p.Thr665Ile, XP_011519303.1:p.Thr665Ile, XP_011519304.1:p.Thr665Ile, XP_011519305.1:p.Thr665Ile, XP_011519306.1:p.Thr665Ile, XP_011519307.1:p.Thr258Ile, XP_011519308.1:p.Thr665Ile, XP_011519309.1:p.Thr665Ile, XP_011519310.1:p.Thr665Ile, XP_011519311.1:p.Thr665Ile, rs386563627, rs52827764, rs60549230
C > T
No VIP available CA VA
rs880054 NC_000012.11:g.988558C>T, NC_000012.12:g.879392C>T, NG_007984.2:g.131334C>T, NM_001184985.1:c.3612+1031C>T, NM_014823.2:c.2370+1031C>T, NM_018979.3:c.2374-181C>T, NM_213655.4:c.3867+1031C>T, XM_005253733.1:c.3613-181C>T, XM_005253734.1:c.2374-181C>T, XM_005253735.1:c.2374-181C>T, XM_005253736.1:c.2290-181C>T, XM_005253737.1:c.2287-181C>T, XM_005253738.1:c.2374-181C>T, XM_005253739.1:c.2370+1031C>T, XM_005253740.1:c.2289+1031C>T, XM_005253741.1:c.2286+1031C>T, XM_005253742.1:c.2289+1031C>T, XM_005253743.1:c.1153-181C>T, XM_006719003.1:c.2371-181C>T, XM_011520997.1:c.3613-181C>T, XM_011520998.1:c.3610-181C>T, XM_011520999.1:c.3613-181C>T, XM_011521000.1:c.3613-181C>T, XM_011521001.1:c.3613-181C>T, XM_011521002.1:c.3609+1031C>T, XM_011521003.1:c.3612+1031C>T, XM_011521004.1:c.3609+1031C>T, XM_011521005.1:c.2392-181C>T, XM_011521006.1:c.2290-181C>T, XM_011521007.1:c.2287-181C>T, XM_011521008.1:c.2289+1031C>T, XM_011521009.1:c.2286+1031C>T, rs17223434
C > T
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147


Alternate Names:  HSN2; PRKWNK1; protein phosphatase 1, regulatory subunit 167
Alternate Symbols:  HSAN2; PPP1R167
PharmGKB Accession Id: PA33782


Cytogenetic Location: chr12 : p13.33 - p13.33
GP mRNA Boundary: chr12 : 861759 - 1020618
GP Gene Boundary: chr12 : 851759 - 1023618
Strand: plus


UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Diuretics Pathway, Pharmacodynamics
    Diagrammatic representation of candidate genes involved in the pharmacodynamics of thiazide diuretics, loop diuretics and potassium-sparing diuretics in a stylized kidney cell.

Curated Information ?

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available

Curated Information ?

Publications related to WNK1: 6

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
WNK kinases and the kidney. Experimental cell research. 2012. Hoorn Ewout J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Polymorphisms, hypertension and thiazide diuretics. Pharmacogenomics. 2011. Citterio Lorena, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation. Hypertension. 2008. Manunta Paolo, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic. Hypertension. 2005. Turner Stephen T, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. Human molecular genetics. 2005. Newhouse Stephen J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The thiazide-sensitive Na(+)-Cl(-) cotransporter gene, C1784T, and adrenergic receptor-beta3 gene, T727C, may be gene polymorphisms susceptible to the antihypertensive effect of thiazide diuretics. Hypertension research : official journal of the Japanese Society of Hypertension. 2004. Matayoshi Tetsutaro, et al. PubMed


NCBI Gene:
UCSC Genome Browser:
RefSeq RNA:
RefSeq Protein:
RefSeq DNA:
Comparative Toxicogenomics Database:
HumanCyc Gene:

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