Gene:
PRKDC
protein kinase, DNA-activated, catalytic polypeptide

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  HYRC; HYRC1
Alternate Symbols:  DNA-PKcs; DNAPK; DNPK1; XRCC7; p350
PharmGKB Accession Id: PA33776

Details

Cytogenetic Location: chr8 : q11.21 - q11.21
GP mRNA Boundary: chr8 : 48685669 - 48872743
GP Gene Boundary: chr8 : 48682669 - 48882743
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

External Pathways

Links to non-PharmGKB pathways.

PharmGKB contains no links to external pathways for this gene. To report a pathway, click here.

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
H2AFX

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
chlorambucil

Curated Information ?

Publications related to PRKDC: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gene network analysis of oxidative stress-mediated drug sensitivity in resistant ovarian carcinoma cells. The pharmacogenomics journal. 2010. Maiti A K. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer cell. 2002. Yeoh Eng-Juh, et al. PubMed

LinkOuts

NCBI Gene:
5591
OMIM:
600899
UCSC Genome Browser:
NM_006904
RefSeq RNA:
NM_001081640
NM_006904
RefSeq Protein:
NP_001075109
NP_008835
RefSeq DNA:
NG_023435
NT_008183
UniProtKB:
PRKDC_HUMAN (P78527)
Ensembl:
ENSG00000121031
ENSG00000253729
GenAtlas:
PRKDC
GeneCard:
PRKDC
MutDB:
PRKDC
ALFRED:
LO012823Q
HuGE:
PRKDC
Comparative Toxicogenomics Database:
5591
ModBase:
Q9UME3
HumanCyc Gene:
HS04461
HGNC:
9413

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