Gene:
PPP1CB
protein phosphatase 1, catalytic subunit, beta isozyme

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  PP-1B; PP1B; PP1beta
PharmGKB Accession Id: PA33610

Details

Cytogenetic Location: chr2 : p23.2 - p23.2
GP mRNA Boundary: chr2 : 28974614 - 29025806
GP Gene Boundary: chr2 : 28964614 - 29028806
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to PPP1CB: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nature genetics. 2003. Cheok Meyling H, et al. PubMed

LinkOuts

NCBI Gene:
5500
OMIM:
600590
UCSC Genome Browser:
NM_002709
RefSeq RNA:
NM_002709
NM_206876
RefSeq Protein:
NP_002700
NP_996759
RefSeq DNA:
NT_022184
UniProtKB:
PP1B_HUMAN (P62140)
Ensembl:
ENSG00000213639
GenAtlas:
PPP1CB
GeneCard:
PPP1CB
MutDB:
PPP1CB
ALFRED:
LO067352X
HuGE:
PPP1CB
Comparative Toxicogenomics Database:
5500
ModBase:
P62140
HumanCyc Gene:
HS08941
HGNC:
9282

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