Gene:
PPBP
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  THBGB1; beta-thromboglobulin; connective tissue-activating peptide III; neutrophil-activating peptide-2; platelet basic protein
Alternate Symbols:  Beta-TG; CTAP3; CTAPIII; CXCL7; LA-PF4; LDGF; MDGF; NAP-2; NAP-2-L1; PBP; SCYB7; TGB; TGB1; b-TG1
PharmGKB Accession Id: PA33561

Details

Cytogenetic Location: chr4 : q12 - q13.3
GP mRNA Boundary: chr4 : 74852156 - 74853907
GP Gene Boundary: chr4 : 74849156 - 74863907
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. Exocytosis of Alpha granule - (Reactome via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
atorvastatin
No related diseases are available

Publications related to PPBP: 1

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Epithelial neutrophil-activating peptide (ENA-78), acute coronary syndrome prognosis, and modulatory effect of statins. PloS one. 2008. Zineh Issam, et al. PubMed

LinkOuts

NCBI Gene:
5473
OMIM:
121010
UCSC Genome Browser:
NM_002704
RefSeq RNA:
NM_002704
RefSeq Protein:
NP_002695
RefSeq DNA:
NT_022778
UniProtKB:
CXCL7_HUMAN (P02775)
Ensembl:
ENSG00000163736
GenAtlas:
PPBP
GeneCard:
PPBP
MutDB:
PPBP
ALFRED:
LO253568D
HuGE:
PPBP
Comparative Toxicogenomics Database:
5473
ModBase:
P02775
HumanCyc Gene:
HS08924
HGNC:
9240

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