POU class 5 homeobox 1

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for POU5F1

Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
No VIP available CA VA
rs3130501 NC_000006.11:g.31136453A=, NC_000006.11:g.31136453A>G, NC_000006.12:g.31168676A=, NC_000006.12:g.31168676A>G, NM_001173531.2:c.-2248C>T, NM_001173531.2:c.-2248T>C, NM_001285986.1:c.-3037C>T, NM_001285986.1:c.-3037T>C, NM_001285987.1:c.-2509C>T, NM_001285987.1:c.-2509T>C, NM_002701.5:c.405+1540C>T, NM_002701.5:c.405+1540T>C, NM_203289.5:c.-2734C>T, NM_203289.5:c.-2734T>C, NT_113891.2:g.2651220G=, NT_113891.2:g.2651220G>A, NT_113891.3:g.2651114G=, NT_113891.3:g.2651114G>A, NT_167245.1:g.2433591G=, NT_167245.1:g.2433591G>A, NT_167245.2:g.2428006G=, NT_167245.2:g.2428006G>A, NT_167246.1:g.2484812G=, NT_167246.1:g.2484812G>A, NT_167246.2:g.2479192G=, NT_167246.2:g.2479192G>A, NT_167247.1:g.2518391G=, NT_167247.1:g.2518391G>A, NT_167247.2:g.2512806G=, NT_167247.2:g.2512806G>A, NT_167248.1:g.2432322G=, NT_167248.1:g.2432322G>A, NT_167248.2:g.2426726G=, NT_167248.2:g.2426726G>A, NT_167249.1:g.2471406G=, NT_167249.1:g.2471406G>A, NT_167249.2:g.2472108G=, NT_167249.2:g.2472108G>A, rs115164593, rs117532372, rs57279569
A > G
No VIP available CA VA
rs3130931 NC_000006.11:g.31134888T=, NC_000006.11:g.31134888T>C, NC_000006.12:g.31167111T=, NC_000006.12:g.31167111T>C, NM_001173531.2:c.-683A=, NM_001173531.2:c.-683A>G, NM_001285986.1:c.-1472A=, NM_001285986.1:c.-1472A>G, NM_001285987.1:c.-944A=, NM_001285987.1:c.-944A>G, NM_002701.5:c.406-1064A>G, NM_002701.5:c.406-1064G>A, NM_203289.5:c.-1169A=, NM_203289.5:c.-1169A>G, NT_113891.3:g.2649550C=, NT_113891.3:g.2649550C>T, NT_167245.1:g.2432027T=, NT_167245.1:g.2432027T>C, NT_167245.2:g.2426442T=, NT_167245.2:g.2426442T>C, NT_167246.1:g.2483247C=, NT_167246.1:g.2483247C>T, NT_167246.2:g.2477627C=, NT_167246.2:g.2477627C>T, NT_167247.1:g.2516826C=, NT_167247.1:g.2516826C>T, NT_167247.2:g.2511241C=, NT_167247.2:g.2511241C>T, NT_167248.1:g.2430755C=, NT_167248.1:g.2430755C>T, NT_167248.2:g.2425159C=, NT_167248.2:g.2425159C>T, NT_167249.1:g.2469840C=, NT_167249.1:g.2469840C>T, NT_167249.2:g.2470542C=, NT_167249.2:g.2470542C>T, XM_005272868.1:c.*103C=, XM_005272868.1:c.*103C>T, rs116274342, rs118179370, rs57720136, rs9263801
T > G
T > T
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147


Alternate Names:  OTF3
Alternate Symbols:  MGC22487; OCT3; Oct4
PharmGKB Accession Id: PA33545


Cytogenetic Location: chr6 : p21.31 - p21.33
GP mRNA Boundary: chr6 : 31132114 - 31138451
GP Gene Boundary: chr6 : 31129114 - 31148451
Strand: minus


UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to POU5F1: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Significant association of combination of OCT4, NANOG, and SOX2 gene polymorphisms in susceptibility and response to treatment in North Indian breast cancer patients. Cancer chemotherapy and pharmacology. 2014. Tulsyan Sonam, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
Genome-Wide Association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. Orphanet journal of rare diseases. 2011. Genin Emmanuelle, et al. PubMed