Gene:
POMC
proopiomelanocortin

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  adrenocorticotropic hormone; adrenocorticotropin; alpha-melanocyte stimulating hormone; beta-endorphin; beta-lipotropin; beta-melanocyte stimulating hormone; opiomelanocortin prepropeptide
Alternate Symbols:  ACTH; CLIP; LPH; MSH; NPP; POC
PharmGKB Accession Id: PA33526

Details

Cytogenetic Location: chr2 : p23.3 - p23.3
GP mRNA Boundary: chr2 : 25383722 - 25391559
GP Gene Boundary: chr2 : 25380722 - 25401559
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Glucocorticoid Pathway (HPA Axis), Pharmacodynamics
    Simplified diagram of the actions of corticotropin releasing factor(CRH) and related hormones which regulate the release of glcocorticoids via the hypothalamic pituitary adrenal axis.

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
CRHR1

Curated Information ?

Publications related to POMC: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder. American journal of human genetics. 2009. Holmans Peter, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Linkage of congenital isolated adrenocorticotropic hormone deficiency to the corticotropin releasing hormone locus using simple sequence repeat polymorphisms. American journal of medical genetics. 1996. Kyllo J H, et al. PubMed

LinkOuts

NCBI Gene:
5443
OMIM:
176830
601665
609734
UCSC Genome Browser:
NM_000939
RefSeq RNA:
NM_000939
NM_001035256
RefSeq Protein:
NP_000930
NP_001030333
MutDB:
POMC
ALFRED:
LO011469V
HuGE:
POMC
Comparative Toxicogenomics Database:
5443
HumanCyc Gene:
HS03838
HGNC:
9201

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