Gene:
PFKM
phosphofructokinase, muscle

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  PFKX; protein phosphatase 1, regulatory subunit 122
Alternate Symbols:  PFK-1; PPP1R122
PharmGKB Accession Id: PA33216

Details

Cytogenetic Location: chr12 : q13.3 - q13.11
GP mRNA Boundary: chr12 : 48499656 - 48540187
GP Gene Boundary: chr12 : 48489656 - 48543187
Strand: plus
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

LinkOuts

UniProtKB:
K6PF_HUMAN (P08237)
Ensembl:
ENSG00000152556
GenAtlas:
PFKM
GeneCard:
PFKM
MutDB:
PFKM
ALFRED:
LO045923X
HuGE:
PFKM
Comparative Toxicogenomics Database:
5213
ModBase:
P08237
HumanCyc Gene:
HS07832
HGNC:
8877

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