3-phosphoinositide dependent protein kinase 1

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PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Alternate Names:  3-phosphoinositide dependent protein kinase-1; PkB kinase
Alternate Symbols:  PDK1
PharmGKB Accession Id: PA33160


Cytogenetic Location: chr16 : p13.3 - p13.3
GP mRNA Boundary: chr16 : 2587970 - 2653189
GP Gene Boundary: chr16 : 2577970 - 2656189
Strand: plus


UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. actions of nitric oxide in the heart - (BioCarta via Pathway Interaction Database)
  2. Activation of PKB - (Reactome via Pathway Interaction Database)
  3. AKT phosphorylates targets in the cytosol - (Reactome via Pathway Interaction Database)
  4. akt signaling pathway - (BioCarta via Pathway Interaction Database)
  5. b cell survival pathway - (BioCarta via Pathway Interaction Database)
  6. BCR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  7. Class I PI3K signaling events - (Pathway Interaction Database NCI-Nature Curated)
  8. Class I PI3K signaling events mediated by Akt - (Pathway Interaction Database NCI-Nature Curated)
  9. control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) - (BioCarta via Pathway Interaction Database)
  10. corticosteroids and cardioprotection - (BioCarta via Pathway Interaction Database)
  11. Downstream TCR signaling - (Reactome via Pathway Interaction Database)
  12. FGF signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  13. human cytomegalovirus and map kinase pathways - (BioCarta via Pathway Interaction Database)
  14. IGF1 pathway - (Pathway Interaction Database NCI-Nature Curated)
  15. il-2 receptor beta chain in t cell activation - (BioCarta via Pathway Interaction Database)
  16. inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages - (BioCarta via Pathway Interaction Database)
  17. influence of ras and rho proteins on g1 to s transition - (BioCarta via Pathway Interaction Database)
  18. Insulin Pathway - (Pathway Interaction Database NCI-Nature Curated)
  19. mtor signaling pathway - (BioCarta via Pathway Interaction Database)
  20. mTOR signaling pathway - (Pathway Interaction Database NCI-Nature Curated)
  21. nfat and hypertrophy of the heart - (BioCarta via Pathway Interaction Database)
  22. phosphoinositides and their downstream targets - (BioCarta via Pathway Interaction Database)
  23. phospholipase c signaling pathway - (BioCarta via Pathway Interaction Database)
  24. phospholipids as signalling intermediaries - (BioCarta via Pathway Interaction Database)
  25. PI3K/AKT signalling - (Reactome via Pathway Interaction Database)
  26. ras signaling pathway - (BioCarta via Pathway Interaction Database)
  27. regulation of bad phosphorylation - (BioCarta via Pathway Interaction Database)
  28. regulation of eif-4e and p70s6 kinase - (BioCarta via Pathway Interaction Database)
  29. role of erbb2 in signal transduction and oncology - (BioCarta via Pathway Interaction Database)
  30. role of erk5 in neuronal survival pathway - (BioCarta via Pathway Interaction Database)
  31. role of nicotinic acetylcholine receptors in the regulation of apoptosis - (BioCarta via Pathway Interaction Database)
  32. Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met) - (Pathway Interaction Database NCI-Nature Curated)
  33. Signaling events mediated by Stem cell factor receptor (c-Kit) - (Pathway Interaction Database NCI-Nature Curated)
  34. Signaling events mediated by VEGFR1 and VEGFR2 - (Pathway Interaction Database NCI-Nature Curated)
  35. skeletal muscle hypertrophy is regulated via akt-mtor pathway - (BioCarta via Pathway Interaction Database)
  36. TCR signaling in naïve CD4+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  37. TCR signaling in naïve CD8+ T cells - (Pathway Interaction Database NCI-Nature Curated)
  38. TGF-beta receptor signaling - (Pathway Interaction Database NCI-Nature Curated)
  39. the igf-1 receptor and longevity - (BioCarta via Pathway Interaction Database)
  40. transcription factor creb and its extracellular signals - (BioCarta via Pathway Interaction Database)
  41. trefoil factors initiate mucosal healing - (BioCarta via Pathway Interaction Database)
  42. Trk receptor signaling mediated by PI3K and PLC-gamma - (Pathway Interaction Database NCI-Nature Curated)
  43. trka receptor signaling pathway - (BioCarta via Pathway Interaction Database)
  44. vegf hypoxia and angiogenesis - (BioCarta via Pathway Interaction Database)
  45. VEGFR1 specific signals - (Pathway Interaction Database NCI-Nature Curated)


NCBI Gene:
UCSC Genome Browser:
RefSeq RNA:
RefSeq Protein:
RefSeq DNA:
PDPK1_HUMAN (O15530)
Comparative Toxicogenomics Database:
HumanCyc Gene:

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