Gene:
PDE5A
phosphodiesterase 5A, cGMP-specific

PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  None
Alternate Symbols:  None
PharmGKB Accession Id: PA33132

Details

Cytogenetic Location: chr4 : q27 - q26
GP mRNA Boundary: chr4 : 120415550 - 120549981
GP Gene Boundary: chr4 : 120412550 - 120559981
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Curated Information ?

Publications related to PDE5A: 2

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Pharmacogenetics of erectile dysfunction: navigating into uncharted waters. Pharmacogenomics. 2014. Lacchini Riccardo, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proceedings of the National Academy of Sciences of the United States of America. 2006. Wong Ma-Li, et al. PubMed

LinkOuts

NCBI Gene:
8654
OMIM:
603310
UCSC Genome Browser:
NM_001083
RefSeq RNA:
NM_001083
NM_033430
NM_033437
RefSeq Protein:
NP_001074
NP_236914
NP_246273
RefSeq DNA:
NT_016354
UniProtKB:
PDE5A_HUMAN (O76074)
Ensembl:
ENSG00000138735
GenAtlas:
PDE5A
GeneCard:
PDE5A
MutDB:
PDE5A
ALFRED:
LO006024M
HuGE:
PDE5A
Comparative Toxicogenomics Database:
8654
ModBase:
O76074
HumanCyc Gene:
HS06542
HGNC:
8784

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