Gene:
SLC22A2
solute carrier family 22 (organic cation transporter), member 2
PharmGKB contains no prescribing info for this . Contact us to report known genotype-based dosing guidelines, or if you are interested in developing guidelines.
1. Annotation of EMA Label for fampridine and SLC22A2
Summary
The EMA European Public Assessment Report (EPAR) for fampridine (Fampyra) does not contain pharmacogenetic information. It contains information regarding the role of OCT2 (SLC22A2) in the secretion of fampridine, and states that concomitant use of drugs that are onohibitors of OCT2 are contraindicated, and cautions the use of concomitant drugs that are substrates of OCT2.
Annotation
The EMA-approved drug fampridine (Fampyra) is tagged with OCT2 (encoded by the SLC22A2 gene) in [Article:24433361].
Excerpt from the fampridine (Fampyra) EPAR:
Fampridine is eliminated mainly via kidneys with active renal secretion accounting for about 60% (see section 5.2). OCT2 is the transporter responsible for the active secretion of fampridine. Thus, the concomitant use of fampridine with medicinal products that are inhibitors of OCT2 for example, cimetidine are contraindicated (see section 4.3) and concomitant use of fampridine with medicinal products that are substrates of OCT2 for example, carvedilol, propanolol and metformin is cautioned (see section 4.4.)
For the complete drug label text with sections containing pharmacogenetic information highlighted, see the fampridine EMA drug label.
*Disclaimer: The contents of this page have not been endorsed by the EMA and are the sole responsibility of PharmGKB.
Genes and/or phenotypes found in this label
-
Multiple Sclerosis
- efficacy, Indications & usage section, Information for patients section, Adverse reactions section, Pharmacodynamics section
- source: European Medicines Agency
-
SLC22A2
- metabolism/PK, Contraindications section, Drug interactions section, Pharmacokinetics section, Warnings and precautions section
- source: European Medicines Agency
PharmGKB contains no Clinical Variants that meet the highest level of criteria.
To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.
Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.
The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.
The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.
The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.
Links in the "Drugs" column lead to PharmGKB Drug Pages.
List of all variant annotations for SLC22A2
|
Variant?
(147) |
Alternate Names ? | Chemicals ? |
Alleles
?
(+ chr strand) |
Function ? |
Amino Acid?
Translation |
|
|---|---|---|---|---|---|---|
| rs145450955 | NC_000006.11:g.160671651G>A, NC_000006.12:g.160250619G>A, NM_003058.3:c.602C>T, NP_003049.2:p.Thr201Met |
G > A
|
SNP |
T201M
|
||
| rs316003 |
C > T
|
SNP |
V502V
|
|||
| rs316009 |
T > C
|
SNP | ||||
| rs316019 | NC_000006.11:g.160670282A>C, NC_000006.12:g.160249250A>C, NM_003058.3:c.808T>G, NP_003049.2:p.Ser270Ala, rs1755917, rs17846267, rs17859289, rs386580336, rs52803175, rs60007366, rs666224 |
A > C
|
SNP |
S270A
|
||
| rs8177516 | NC_000006.11:g.160664685G>A, NC_000006.12:g.160243653G>A, NM_003058.3:c.1198C>T, NP_003049.2:p.Arg400Cys, rs52794771, rs59822044 |
G > A
|
SNP |
R400C
|
Overview
| Alternate Names: | None |
|---|---|
| Alternate Symbols: | OCT2 |
| PharmGKB Accession Id: | PA331 |
Details
| Cytogenetic Location: | chr6 : q25.3 - q25.3 |
|---|---|
| GP mRNA Boundary†: | chr6 : 160637794 - 160679963 |
| GP Gene Boundary†: | chr6 : 160634794 - 160689963 |
| Strand: | minus |
Visualization
UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.
View on UCSC BrowserPharmGKB Curated Pathways
Pathways created internally by PharmGKB based primarily on literature evidence.
-
Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics
Representation of candidate genes involved in the metabolism of lamivudine and its mechanism of antiviral action.
-
Metformin Pathway, Pharmacokinetics
Schematic representation of metformin transport.
-
Pazopanib Pathway, Pharmacokinetics
Stylized representation of pazopanib transport and metabolism in the liver.
Curated Information ?
| Evidence | Drug |
|---|---|
| cisplatin | |
| daunorubicin | |
| dolutegravir | |
| doxorubicin | |
| fampridine | |
| l-tryptophan | |
| lamivudine | |
| metformin | |
| ranolazine | |
| sulfamethoxazole | |
| trimethoprim | |
| vandetanib |
| Evidence | Drug Class |
|---|---|
| anthracyclines and related substances | |
| Platinum compounds |
Curated Information ?
Publications related to SLC22A2: 52
LinkOuts
- UniProtKB:
- S22A2_HUMAN (O15244)
- Ensembl:
- ENSG00000112499
- GenAtlas:
- SLC22A2
- GeneCard:
- SLC22A2
- MutDB:
- SLC22A2
- ALFRED:
- LO049456C