Gene:
SLC18A2
solute carrier family 18 (vesicular monoamine transporter), member 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for SLC18A2

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available No Clinical Annotations available VA
rs14240 NC_000010.10:g.119037071T>C, NC_000010.11:g.117277560T>C, NM_003054.4:c.*294T>C, XR_246069.1:n.1581-7117A>G, rs3168025, rs363234, rs3758625, rs386491448, rs60529903
T > C
SNP
No VIP available No Clinical Annotations available VA
rs363224 NC_000010.10:g.119022573C>A, NC_000010.11:g.117263062C>A, NM_003054.4:c.992-3671C>A, rs17543598, rs56467431, rs57914512
C > A
SNP
No VIP available No Clinical Annotations available VA
rs363343 NC_000010.10:g.119014948C>A, NC_000010.11:g.117255437C>A, NM_003054.4:c.791-42C>A, rs58082994
C > A
SNP
No VIP available No Clinical Annotations available VA
rs363371 NC_000010.10:g.118986396G>A, NC_000010.11:g.117226885G>A, rs56433345, rs60933142
G > A
SNP
No VIP available No Clinical Annotations available VA
rs363390 NC_000010.10:g.119004079G>C, NC_000010.11:g.117244568G>C, NM_003054.4:c.464+255G>C, XR_946342.1:n.-1805C>G, rs59729204
G > C
SNP
No VIP available No Clinical Annotations available VA
rs929493 NC_000010.10:g.119019126C>T, NC_000010.11:g.117259615C>T, NM_003054.4:c.991+1723C>T, rs59180434, rs60438643
C > T
SNP
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  VMAT2; solute carrier family 18 (vesicular monoamine), member 2
Alternate Symbols:  SVAT; SVMT
PharmGKB Accession Id: PA325

Details

Cytogenetic Location: chr10 : q25.3 - q25.3
GP mRNA Boundary: chr10 : 119000584 - 119038941
GP Gene Boundary: chr10 : 118990584 - 119041941
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Representation of genes involved in nicotine effects in dopaminergic neurons.
  1. Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
    Genes involved in serotonin synthesis, release, reuptake, and in mediation of the antidepressant effect of selective serotonin reuptake inhibitors (SSRI) in human brain.
  1. Sympathetic Nerve Pathway (Neuroeffector Junction)
    Simplified diagram of a sympathetic neuroeffector junction displaying genes which may be involved.

External Pathways

Links to non-PharmGKB pathways.

  1. Dopamine Neurotransmitter Release Cycle - (Reactome via Pathway Interaction Database)
  2. Norepinephrine Neurotransmitter Release Cycle - (Reactome via Pathway Interaction Database)
  3. Serotonin Neurotransmitter Release Cycle - (Reactome via Pathway Interaction Database)
No related genes are available

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
antipsychotics
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
xenobiotics

Curated Information ?

Publications related to SLC18A2: 10

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry. Pharmacogenomics. 2015. Levran Orna, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Association study of the vesicular monoamine transporter gene SLC18A2 with tardive dyskinesia. Journal of psychiatric research. 2013. Zai Clement C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Genetic variation in the proximal promoter of ABC and SLC superfamilies: liver and kidney specific expression and promoter activity predict variation. PloS one. 2009. Hesselson Stephanie E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available VA No VIP available No VIP available
Variation in the genes encoding vesicular monoamine transporter 2 and beta-1 adrenergic receptor and antidepressant treatment outcome. Psychiatric genetics. 2008. Crowley James J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Normal biogenesis and cycling of empty synaptic vesicles in dopamine neurons of vesicular monoamine transporter 2 knockout mice. Molecular biology of the cell. 2005. Croft Benjamin G, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The effect of rare human sequence variants on the function of vesicular monoamine transporter 2. Pharmacogenetics. 2004. Burman Jonathon, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Screening a large reference sample to identify very low frequency sequence variants: comparisons between two genes. Nature genetics. 2001. Glatt C E, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The photoactivatable inhibitor 7-azido-8-iodoketanserin labels the N terminus of the vesicular monoamine transporter from bovine chromaffin granules. Biochemistry. 1997. Sagné C, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
ftp://ftpguest:4guest@ftp.pharmgkb.org/download/PKB_N00000012.html. [URL:ftp://ftpguest:4guest@ftp.pharmgkb.org/download/PKB_N00000012.html]
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
http://pharmacogenetics.ucsf.edu/public-results/vmat2/. [URL:http://pharmacogenetics.ucsf.edu/public-results/vmat2/]

LinkOuts

NCBI Gene:
6571
OMIM:
193001
UCSC Genome Browser:
NM_003054
RefSeq RNA:
NM_003054
RefSeq Protein:
NP_003045
RefSeq DNA:
NT_030059
UniProtKB:
VMAT2_HUMAN (Q05940)
Ensembl:
ENSG00000165646
GenAtlas:
SLC18A2
GeneCard:
SLC18A2
MutDB:
SLC18A2
ALFRED:
LO002089T
HuGE:
SLC18A2
Comparative Toxicogenomics Database:
6571
ModBase:
Q05940
HumanCyc Gene:
HS09261
HGNC:
10935

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