Gene:
NRG2
neuregulin 2

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  divergent of neuregulin-1; neural- and thymus-derived activator for ErbB kinases
Alternate Symbols:  Don-1; HRG2; NTAK
PharmGKB Accession Id: PA31777

Details

Cytogenetic Location: chr5 : q31.2 - q31.2
GP mRNA Boundary: chr5 : 139226364 - 139422884
GP Gene Boundary: chr5 : 139223364 - 139432884
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

  1. EGFR Inhibitor Pathway, Pharmacodynamics
    Model non-tissue specific cancer cell displaying genes that may be involved in the treatment using epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies.

Curated Information ?

Evidence Gene
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
EGFR
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ERBB2
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ERBB3
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
ERBB4

Curated Information ?

Evidence Drug
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
cetuximab
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available PW
panitumumab
No related diseases are available

LinkOuts

NCBI Gene:
9542
OMIM:
603818
UCSC Genome Browser:
NM_004883
RefSeq RNA:
NM_001184935
NM_004883
NM_013981
NM_013982
NM_013983
RefSeq Protein:
NP_001171864
NP_004874
NP_053584
NP_053585
NP_053586
RefSeq DNA:
NT_029289
UniProtKB:
NRG2_HUMAN (O14511)
Ensembl:
ENSG00000158458
GenAtlas:
NRG2
GeneCard:
NRG2
MutDB:
NRG2
ALFRED:
LO005180O
HuGE:
NRG2
Comparative Toxicogenomics Database:
9542
ModBase:
O14511
HumanCyc Gene:
HS08292
HGNC:
7998

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