Gene:
NCOA1
nuclear receptor coactivator 1

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

To see more Clinical Variants with lower levels of criteria, click the button at the bottom of the table.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

? = Mouse-over for quick help

The table below contains information about pharmacogenomic variants on PharmGKB. Please follow the link in the "Variant" column for more information about a particular variant. Each link in the "Variant" column leads to the corresponding PharmGKB Variant Page. The Variant Page contains summary data, including PharmGKB manually curated information about variant-drug pairs based on individual PubMed publications. The PMIDs for these PubMed publications can be found on the Variant Page.

The tags in the first column of the table indicate what type of information can be found on the corresponding Variant Page on the appropriate tab.

Links in the "Drugs" column lead to PharmGKB Drug Pages.

List of all variant annotations for NCOA1

Variant?
(147)
Alternate Names ? Chemicals ? Alleles ?
(+ chr strand)
Function ? Amino Acid?
Translation
No VIP available CA VA
rs1804645 NC_000002.11:g.24974958C>T, NC_000002.12:g.24752089C>T, NG_029014.1:g.172613C>T, NM_003743.4:c.3814C>T, NM_147223.2:c.3814C>T, NM_147233.2:c.3814C>T, NP_003734.3:p.Pro1272Ser, NP_671756.1:p.Pro1272Ser, NP_671766.1:p.Pro1272Ser, XM_005264625.1:c.3814C>T, XM_005264626.1:c.3814C>T, XM_005264627.1:c.3814C>T, XM_005264628.1:c.3814C>T, XM_011533141.1:c.3499C>T, XP_005264682.1:p.Pro1272Ser, XP_005264683.1:p.Pro1272Ser, XP_005264684.1:p.Pro1272Ser, XP_005264685.1:p.Pro1272Ser, XP_011531443.1:p.Pro1167Ser, rs17838346
C > T
SNP
P1272S
Alleles, Functions, and Amino Acid Translations are all sourced from dbSNP 147

Overview

Alternate Names:  None
Alternate Symbols:  F-SRC-1; KAT13A; NCoA-1; RIP160; SRC1; bHLHe74
PharmGKB Accession Id: PA31470

Details

Cytogenetic Location: chr2 : p23.3 - p23.3
GP mRNA Boundary: chr2 : 24714919 - 24993571
GP Gene Boundary: chr2 : 24704919 - 24996571
Strand: plus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.
No related genes are available

Curated Information ?

Evidence Drug Class
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
glucocorticoids

Curated Information ?

Evidence Disease
No Dosing Guideline available No Drug Label available CA No Variant Annotation available No VIP available No VIP available
Breast Neoplasms

Publications related to NCOA1: 6

No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Aromatase inhibitor-induced modulation of breast density: clinical and genetic effects. British journal of cancer. 2013. Henry N L, et al. PubMed
No Dosing Guideline available No Drug Label available CA VA No VIP available No VIP available
A SNP in Steroid Receptor Coactivator-1 Disrupts a GSK3beta Phosphorylation Site and Is Associated with Altered Tamoxifen Response in Bone. Molecular endocrinology (Baltimore, Md.). 2011. Hartmaier R J, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression. Drug metabolism and disposition: the biological fate of chemicals. 2008. Svecova Lucie, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. The Journal of biological chemistry. 2003. Litterst Claudia M, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics. The Journal of biological chemistry. 2002. Takeshita Akira, et al. PubMed
No Dosing Guideline available No Drug Label available No Clinical Annotation available No Variant Annotation available No VIP available No VIP available
The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. The Journal of clinical investigation. 1998. Lehmann J M, et al. PubMed

LinkOuts

NCBI Gene:
8648
OMIM:
602691
UCSC Genome Browser:
NM_003743
RefSeq RNA:
NM_003743
NM_147223
NM_147233
RefSeq Protein:
NP_003734
NP_671756
NP_671766
RefSeq DNA:
NT_022184
UniProtKB:
NCOA1_HUMAN (Q15788)
Ensembl:
ENSG00000084676
GenAtlas:
NCOA1
GeneCard:
NCOA1
MutDB:
NCOA1
ALFRED:
LO066888K
HuGE:
NCOA1
Comparative Toxicogenomics Database:
8648
ModBase:
Q6GVI5
HumanCyc Gene:
HS01476
HGNC:
7668

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