Gene:
MST1R
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)

PharmGKB contains no dosing guidelines for this . To report known genotype-based dosing guidelines, or if you are interested in developing guidelines, click here.

PharmGKB has no annotated drug labels with pharmacogenomic information for this . If you know of a drug label with PGx, send us a message.

PharmGKB contains no Clinical Variants that meet the highest level of criteria.

Disclaimer: The PharmGKB's clinical annotations reflect expert consensus based on clinical evidence and peer-reviewed literature available at the time they are written and are intended only to assist clinicians in decision-making and to identify questions for further research. New evidence may have emerged since the time an annotation was submitted to the PharmGKB. The annotations are limited in scope and are not applicable to interventions or diseases that are not specifically identified.

The annotations do not account for individual variations among patients, and cannot be considered inclusive of all proper methods of care or exclusive of other treatments. It remains the responsibility of the health-care provider to determine the best course of treatment for a patient. Adherence to any guideline is voluntary, with the ultimate determination regarding its application to be made solely by the clinician and the patient. PharmGKB assumes no responsibility for any injury or damage to persons or property arising out of or related to any use of the PharmGKB clinical annotations, or for any errors or omissions.

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Overview

Alternate Names:  PTK8; RON
Alternate Symbols:  CD136; CDw136
PharmGKB Accession Id: PA31186

Details

Cytogenetic Location: chr3 : p21.31 - p21.31
GP mRNA Boundary: chr3 : 49924435 - 49941306
GP Gene Boundary: chr3 : 49921435 - 49951306
Strand: minus

Visualization

UCSC has a Genome Browser that you can use to view PharmGKB annotations for this gene in context with many other sources of information.

View on UCSC Browser
The mRNA boundaries are calculated using the gene's default feature set from NCBI, mapped onto the UCSC Golden Path. PharmGKB sets gene boundaries by expanding the mRNA boundaries by no less than 10,000 bases upstream (5') and 3,000 bases downstream (3') to allow for potential regulatory regions.

PharmGKB Curated Pathways

Pathways created internally by PharmGKB based primarily on literature evidence.

PharmGKB contains no curated pathways for this gene. If you would like to volunteer to work on a pathway, please let us know.

External Pathways

Links to non-PharmGKB pathways.

  1. a6b1 and a6b4 Integrin signaling - (Pathway Interaction Database NCI-Nature Curated)
  2. amb2 Integrin signaling - (Pathway Interaction Database NCI-Nature Curated)

LinkOuts

Entrez Gene:
4486
OMIM:
600168
UCSC Genome Browser:
NM_002447
RefSeq RNA:
NM_002447
RefSeq Protein:
NP_002438
RefSeq DNA:
AC_000046
AC_000135
NC_000003
NT_022517
NW_001838877
NW_921651
UniProtKB:
RON_HUMAN (Q04912)
Ensembl:
ENSG00000164078
GenAtlas:
MST1R
GeneCard:
MST1R
MutDB:
MST1R
ALFRED:
LO068292B
HuGE:
MST1R
Comparative Toxicogenomics Database:
4486
ModBase:
Q04912
HumanCyc Gene:
HS09003
HGNC:
7381

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